Abstract
Para-aortic lymph node (PALN) dissection is optional and controversial in patients with stage IB1-IIA2 cervical cancer. This retrospective study investigated PALN involvement patterns and evaluated preoperative clinical factors. A total of 723 consecutive FIGO stage IB1-IIA2 cervical cancer patients were included in the study. All patients underwent radical hysterectomy/radical trachelectomy, pelvic lymph node dissection, and PALN dissection. PALN metastasis was found in 101 (14.0%) patients, and the positive PALN rates of stage IB1, IB2, IIA1, and IIA2 were 8.4%, 11.1%, 17.2% and 21.7%, respectively. A multivariate model suggested age > 46 years (OR: 1.67, 95% confidence interval (CI): 1.08-2.58), tumor size > 3.5 cm (OR: 1.79, 95% CI: 1.12-2.87), and FIGO stage IIA (vs. IB) (OR: 1.97, 95% CI: 1.25-3.11) all positively correlated with PALN metastasis. When squamous cervical cancer cases were categorically analyzed, a multivariate model indicated age > 46 years (OR: 1.67, 95% CI: 1.00-2.80), FIGO stage IIA (vs. IB) (OR: 1.76, 95% CI: 1.02-3.02), and squamous cell carcinoma antigen (SCCA) > 6.5 ng/ml (OR: 5.20, 95% CI: 3.07-8.81) all positively correlated with PALN metastasis. Age, tumor size, and FIGO stage correlated with PALN metastasis in cervical cancer, while age, FIGO stage, and SCCA level were predictive in squamous cell carcinoma.
Highlights
The most recent data from GLOBOCAN 2012 showed the global incidence of cervical cancer was about 527,600 with an annual mortality of 265,700 [1]
A total of 723 consecutive International Federation of Gynecology and Obstetrics (FIGO) stage IB1-IIA2 cervical cancer patients who underwent pelvic and paraaortic lymphadenectomy were analyzed in this study
We retrospectively inquired into the relationship between clinical factors and para-aortic lymph nodes (PALN) metastasis in patients with stage IB1-IIA2 cervical cancer
Summary
The most recent data from GLOBOCAN 2012 showed the global incidence of cervical cancer was about 527,600 with an annual mortality of 265,700 [1]. Each year there are about 98,000 cervical cancer patients newly diagnosed in China [2], it is of great importance to optimize individual treatment of cervical cancer. Lymph node (LN) metastasis is an independent prognostic factor for cervical cancer patients [3, 4]. The adjacent obturator nodes will be the first site of LN metastasis, it will spread in a step-wise fashion to the ipsilateral common iliac lymph nodes and para-aortic lymph nodes (PALN). Patients with PALN metastasis have lower survival rates and need extended field radiation. Dissection of enlarged PALN itself could have potential treatment value
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
