Abstract
Aim:To determine the rate, repartition and risk factors of lymph node (LN) metastasis in patients with epithelial ovarian cancer. Methods: We reviewed retrospectively the pathological and clinical data of 184 patients with epithelial ovarian cancer at atertiary care center in Beirut, Lebanon. Results: 88% of patients received a pelvic and para-aortic lymphadenectomy. 70% of patients presentedLN metastases at both pelvic and para-aortic levels, while isolated pelvic or para-aortic LN metastases were seen in 16and 14% of cases, respectively. In a univariate analysis, the rate of positive LNs was higher in patients with serous histology (65vs33%;p<0.001), high-grade tumors (68vs26%;p<0.001), bilateral adnexal involvement (74vs27%;p<0.001), advanced clinical stage (p<0.001), interval debulking surgery (63.2vs36.8%;p=0.003) and positive peritoneal cytology (79vs26%;p<0.001). In a multivariate analysis, the rate of LN involvement was significantly higher in patients with higher grade, advanced clinical stage and positive peritoneal cytology. Conclusion: Serous histology, grade 3 tumors, positive peritoneal cytology, advanced clinical stage, interval surgery and bilateral adnexal involvement can predict LN metastasis in patients with epithelial ovarian cancer.
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