Predictive Factors of Deep Vein Thrombosis in Gynecologic Cancer Survivors with Lower Extremity Edema: A Single-Center and Retrospective Study.

Jungin Kim,Dong Kyu Kim,Seunghun Park,Tae Hee Kim,Hyun-Jun Kim

doi:10.3390/healthcare8010048

Abstract

This study was conducted to examine predictive factors of deep vein thrombosis (DVT) in gynecologic cancer survivors with lower extremity edema (LEE). In the current single-center, retrospective study, there was a total of 315 eligible patients, including 80 patients with DVT and 235 without DVT. They were therefore divided into two groups: the DVT group (n = 80) and the non-DVT group (n = 235). Then, baseline and clinical characteristics of the patients were compared between the two groups. In our study, distant organ metastasis, advanced stage, lymphadectomy, and amount of intraoperative blood loss had a positive predictive value for the occurrence of DVT in gynecologic cancer survivors presenting LEE. In conclusion, our results indicate that it is necessary to consider the possibility of LEE arising from DVT in gynecologic cancer survivors with advanced-stage cancer, distant organ metastasis, lymphadectomy, and intraoperative blood loss over 1500 mL.

Highlights

The relationship between venous thrombosis and malignancy was first described by Trousseau in1865
According to Virchow, there is a triad of risk factors that contribute to venous thromboembolism; these include venous stasis, endothelial injury, and hypercoagulable states [3]
Results of Univariate and Multivariate Analyses of Possible Predictive Factors. We performed both univariate and multivariate analyses of predictive factors, such as body mass index (BMI), distant organ metastasis, advanced stage, lymphadectomy, operation time ≥3 hours, and amount of intraoperative blood loss ≥1500 mL, showing a significant difference between the deep vein thrombosis (DVT) group and the non-DVT group. This showed that distant organ metastasis, advanced stage, lymphadectomy, and amount of intraoperative blood loss ≥1500 mL were found to be significant predictive factors (Table 4)

Summary

Introduction

The relationship between venous thrombosis and malignancy was first described by Trousseau in. Since it has been advocated by multiple clinical, pathologic, and laboratory studies [1,2]. According to Virchow, there is a triad of risk factors that contribute to venous thromboembolism; these include venous stasis, endothelial injury, and hypercoagulable states [3]. Patients with cancer are vulnerable to thrombosis arising from hematologic and biochemical abnormalities. Ovarian cancer cells are capable of forming and degrading thrombin. Gynecologic malignancies are characterized by increased fibrinolytic activity. Patients receiving surgery, chemotherapy, or radiotherapy are at increased risks of developing thrombosis [4,5]

Methods

Results

Discussion

Conclusion