Abstract

Background: Among mechanical traumas, traumatic brain injury (TBI) is the main determinant of deaths and sequelae in polytrauma patients. TBI is defined as any traumatic injury to the brain that results in anatomical injury such as skull fracture or scalp injury, functional impairment of the meninges, brain and its vessels or momentary or permanent brain changes, of a cognitive or physical nature. Objective: The present work aims to conduct a literature review on the factors that are predictive in the prognosis of victims of traumatic brain injury. Methods: This is a literature review based on the medical literature and scientific articles indexed in the Scientific Eletronic Library Online (SCIELO) and VHL-Brazil. Results: Several factors are related to a worse prognosis in patients suffering from TBI, and the most cited are: score equal to or less than 8 on the Glasgow Coma Scale (ECG) on admission; age over 60 years; tomographic changes showing diffuse axonal lesion or cerebral edema; pupils with abolished photomotor reflexes; arterial hypotension at admission; hyperthermia and male sex. Studies address that the initial clinical-neurological severity, measured by ECG, has the greatest significant influence on the evolution of patients, showing that the initial clinical manifestation points out the severity of primary and secondary injuries associated with TBI. As well as ECG, several other factors such as the brain’s susceptibility to injury, the extent and severity of the injuries, the presence of global or focal injuries, associated injuries and the initial response to treatment are also cited as useful in determining the evolution of cases of victims of TCE. Conclusions: It was found that the TBI is the main responsible for high lethality rates in polytrauma patients worldwide and from obtaining these data in recent years, studies have been deepened in order to search for the prognostic factors for TBI. The identification of these indicators has represented a major advance in the search for alternatives to guide the treatment of the patient and estimate the final result.

Highlights

  • Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack

  • Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells

  • The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A

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Summary

Introduction

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones

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