Predictive Factors for Small Intestinal and Colonic Anastomotic Leak: a Multivariate Analysis

Abstract

Anastomotic leak (AL) is a serious complication of intestinal surgery with various predisposing factors. This study aims to assess several risk factors associated with AL after small intestinal and colonic anastomoses through a multivariate analysis. Two hundred twenty-four patients (126 males) with intestinal anastomosis of a median age of 44years were reviewed. Independent factors associated with AL were male gender (OR=2.59, P=0.02), chronic liver disease (CLD) (OR=8.03, P<0.0001), more than one associated comorbidity (OR=5.34, P=0.017), anastomosis conducted as emergency (OR=2.73, P=0.012), colonic anastomosis (OR=2.51, P=0.017), preoperative leukocytosis (OR=2.57, P=0.015), and intraoperative blood transfusion (OR=2.25, P=0.037). Predicative factors significantly associated with AL were male gender, CLD, multiple comorbidities, emergent anastomoses, colonic anastomoses, preoperative leukocytosis, and intraoperative blood transfusion.