Abstract
s / Pancreatology 15 (2015) S1eS141 S52 stromal tissue, which facilitates immune evasion and acts as a barrier for drug delivery. Hence, reprogramming this stromal tissue to allow exposure of the tumor cells to therapeutic treatments is likely to improve the outcome of these patients. Materialsm p53lox/lox; Elas-tTA/TetO-Cre]. Results: Differential expression analysis illustrated that several cellular processes such as extracellular matrix remodeling, growth factor signaling, invasion and metastatic dissemination were significantly upregulated in CAFs. Moreover, these CAFs also displayed a strong pro-inflammatory gene signature including upregulation of chemokine, cytokine and adipocytokine expression. This inflammatory response also involved hyperactivity of AP1/JNK, IL6, Toll-like Receptor and NFKB pathways. Conclusion: We are currently validating some of these pathways, both in vitro and in vivo, with the help of the CRISPR/Cas9 editing technology.
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