Predictive Factors for Platelet Count Variation After Splenectomy in Non-Traumatic Diseases.

Roxana Dragomir,Dana Festila,Calin Cobelschi,Mircea Hogea,Marius Moga

doi:10.3390/jcm8010082

Abstract

Background: The spleen plays a central role in a range of diseases. As such, great emphasis has been placed on the procedure of spleen removal, the benefits and the numerous associated complications. Given the immediate risk of the thrombotic complications, the aim of this study was to evaluate clinical and laboratory patient characteristics in non-traumatic diseases of the spleen, and to investigate possible predictive factors for platelet count variation following the procedure. Methods: A total of 72 patients who underwent splenectomy were included in this retrospective study. Correlation coefficients as well as multiple linear regressions were used to assess the relationship between post-splenectomy platelet count and various preoperative clinical and laboratory patient characteristics. Results: Following multiple linear regression analysis, we determined that 54.93% of post-splenectomy platelet count variation was explained by admission platelet count (p = 0.00), lymphocyte count (p = 0.04), WBC count (p = 0.00), LOS (p = 0.00), patient gender (p = 0.00), spleen accessibility on admission (p = 0.02) and PT (p = 0.00). Conclusions: Platelet count variation following splenectomy for non-traumatic diseases can be predicted by assessing preoperative patient characteristics. The implications of this study suggest that by means of a prediction model, patient care could benefit from assessing and addressing various preoperative factors that lead to these complications.

Highlights

While not being a vital organ in itself, the spleen plays a central role in a variety of diseases, given its special architecture and functions [1]
While attempts to investigate the predictive factors that lead to these complications have been made, we feel confident that enlarging the area of research with a more thorough statistical analysis could greatly benefit patient care [16,17,18,19,20]
Given the immediate risk posed by thrombotic complications associated with the procedure, the aim of this study was to establish predictive factors for platelet count variation in patients who underwent splenectomy for non-traumatic diseases

Summary

Introduction

While not being a vital organ in itself, the spleen plays a central role in a variety of diseases, given its special architecture and functions [1]. Given the immediate risk of the thrombotic complications, the aim of this study was to evaluate clinical and laboratory patient characteristics in non-traumatic diseases of the spleen, and to investigate possible predictive factors for platelet count variation following the procedure. Correlation coefficients as well as multiple linear regressions were used to assess the relationship between post-splenectomy platelet count and various preoperative clinical and laboratory patient characteristics. Conclusions: Platelet count variation following splenectomy for non-traumatic diseases can be predicted by assessing preoperative patient characteristics. The implications of this study suggest that by means of a prediction model, patient care could benefit from assessing and addressing various preoperative factors that lead to these complications

Objectives

Methods

Results

Conclusion