Predictive dynamical behavior of liquid-filled microparticles partitioning in the vicinity of a coronary bifurcation under pulsatile blood flow and arterial distensibility: A two-dimensional study

Abstract

A promising advance of bioengineering consists in the development of micro-nanoparticles as drug delivery vehicles injected intravenously or intraarterialy for targeted treatment. Proficient functioning of drug carries is conditioned by a reliable prediction of pharmacokinetics in human as well as their dynamical behavior once injected in blood stream. In this study we aim to provide a reliable numerical prediction of dynamical behavior of microparticles in human left coronary artery focusing on their behavior in the vicinity of the coronary bifurcation. We investigate the velocity, the deformation and the trajectory of three microparticles upon pulsatile blood flow and arterial compliance with varying the capillary number and the initial vertical position. The study is carried out within physiological conditions to provide accurate results. Fluid–structure interaction is solved by the Arbitrary Lagrangian Eulerian method using the COMSOL Multiphysics software.