Abstract
BackgroundPredictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m2, and long-term prospective study is an optimal choice to explore this problem. Aim of this analysis was to observe this problem during the follow-up of 5 years.MethodsIn a large medical check-up program in Beijing, there were 948 participants with renal function evaluated at baseline and follow-up of 5 years. Physical examinations were performed by well-trained physicians. Blood samples were analyzed by qualified technicians in central laboratory.ResultsMedian rate of renal function decline was 1.46 (0.42–2.91) mL/min/1.73m2/year. Rapid decline of renal function had a prevalence of 23.5% (223 participants). Multivariate linear and Logistic regression analyses confirmed that age, sex, baseline GFR, homocysteine and N-terminal pro B-type natriuretic peptide (NT-proBNP) had independently predictive abilities to renal function decline rate and rapid decline of renal function (p < 0.05 for all). High-sensitivity cardiac troponin T (hs-cTnT), carotid femoral pulse wave velocity and central augmentation index had no statistically independent association with renal function decline rate and rapid decline of renal function (p > 0.05 for all).ConclusionsHomocysteine and NT-proBNP rather than hs-cTnT had independently predictive abilities to rapid decline of renal function in Chinese community-dwelling population without GFR below 60 ml/min/1.73m2. Baseline GFR was an independent factor predicting the rapid decline of renal function. Arterial stiffness and compliance had no independent effect on rapid decline of renal function. This analysis has a significant implication for public health, and changing the homocysteine and NT-proBNP levels might slow the rapid decline of renal function.
Highlights
Predictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m2, and long-term prospective study is an optimal choice to explore this problem
This prospective analysis had the following findings during the follow-up of 5 years in Chinese community-dwelling population without GFR below 60 ml/min/1.73m2: 1. homocysteine and NTproBNP rather than high-sensitivity cardiac troponin T (hs-cTnT) had the independent abilities to predict the rapid decline of renal function, with their higher levels indicating more rapid renal function decline rate; 2. baseline GFR was an independent factor predicting the rapid decline of renal function; 3. elderly and females had a more rapid decline of renal function compared with others; 4. role of hypertension in rapid decline of renal function could not be ignored; 5. arterial stiffness and compliance had no independent effect on rapid decline of renal function
CMDRD equation is more suitable for Chinese community-dwelling population and has superior accuracy than chronic kidney disease (CKD)-EPI equation. This prospective analysis demonstrated that homocysteine and NT-proBNP rather than hs-cTnT had independently predictive abilities to rapid decline of renal function in Chinese community-dwelling population without GFR below 60 ml/min/1.73m2
Summary
Predictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m2, and long-term prospective study is an optimal choice to explore this problem. Aim of this analysis was to observe this problem during the follow-up of 5 years. Fu et al BMC Nephrology (2017) 18:331 abilities of cardiovascular biomarkers to renal function decline are more significant in community-dwelling population without GFR below 60 ml/min/1.73m2, and it is essential to analyze this problem in this population. These cardiovascular biomarkers might play an etiologic role in renal function decline, and analyzing their relationships could promote the development of preventive strategies to slow the rapid decline of renal function
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
