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Abstract
The repeated amino acid sequences in human acute myeloid leukaemia 1 protein (AML-1) are indispensable for its function and such repetitions cannot be simply attributed to chance. In order to fully explore the functional units in human AML-1, it may be necessary to analyse all the amino acid pairs, triplets, etc. along human AML-1 from one terminal to the next, to count their frequencies and calculate their probabilities. The amino-acid sequence of human AML-1 was counted according to two-, three- and four-amino acid sequences. The counted frequency and probability were compared with the predicted frequency and probability. The amino acid sequences, which appear in human AML-1 and can be predicted from its amino acid composition according to a purely random mechanism, are not deliberately evolved or conserved. By contrast, the amino acid sequences, which appear in human AML-1 but cannot be predicted from its amino acid composition according to a purely random mechanism, are deliberately evolved and conserved. Accordingly 77 (17.035%) and 41 (9.071%) of 452 two-amino acid sequences can be predicted by the frequency and probability according to a purely random mechanism. Some kinds of amino acid sequences, which are absent from human AML-1 but can be predicted from its amino acid composition according to a purely random mechanism, should not be excluded as possibilities in human AML-1. By contrast, some kinds of amino acid sequences, which are absent from human AML-1 and cannot be predicted from its amino acid composition according to a purely random mechanism, can be appropriately excluded from human AML-1. Accordingly 115 (63.187%) and 52 (28.571%) of 182 kinds of absent two-amino-acid sequences can be predicted by the frequency and probability according to a purely random mechanism and 7567 (99.881%) of 7576 kinds of absent three-amino-acid sequences can be predicted by the frequency according to a purely random mechanism.
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