Abstract
BackgroundThere are currently no reliable predictive factors for gastric cancer recurrence. The aim of this study was to evaluate the relationship between bcl-2 expression and risk of gastric cancer recurrence.MethodsFrom January 1996 to December 2007, 449 gastric cancer patients who underwent curative resection were retrospectively studied. The expression levels of bcl-2 were examined by immunohistochemistry. Logistic regression was performed to identify independent risk factors for overall recurrence of gastric cancer.Results151 patients (33.6%) experienced recurrences. The median time to recurrence was 17.0 months, 113 (74.8%) patients had recurrences within 2 years. Peritoneal recurrence was the most prevalent pattern, followed by hematogenous metastasis in which the liver was the most common site. Depth of invasion, lymph node metastases, and negative expression of bcl-2 were independent risk factors for overall recurrence. The overall survival time of recurrent patients was 22.7 months. The median survival time after recurrence was 6.7 months.ConclusionThe depth of invasion, lymph node metastases and expression of bcl-2 are independent factors for predicting gastric cancer recurrence.
Highlights
There are currently no reliable predictive factors for gastric cancer recurrence
We evaluated the prognostic value of biological markers such as p53, bcl-2, bax, and c-myc in gastric cancer, and found that bcl-2 was significantly associated with prognosis in gastric cancer patients [7]
Lymph node metastasis was observed in 326 patients, and the metastasis rate was 72.6%
Summary
There are currently no reliable predictive factors for gastric cancer recurrence. The aim of this study was to evaluate the relationship between bcl-2 expression and risk of gastric cancer recurrence. The majority of patients with early-stage gastric cancer can have long survival times after surgery, approximately 40% of patients die from recurrence, even after undergoing curative surgery [3]. It is very important to precisely predict the risk of recurrence at an early stage in order to improve prognosis of patients with recurrence. It has been demonstrated that routine followup after surgery for of the current study is to determine whether bcl-2 expression can predict disease recurrence after curative resection in patients with gastric cancer
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