Prediction of treatment response following ethanol sclerotherapy of renal cysts by computed tomography.

Abstract

To investigate predictive factors of treatment response following ethanol sclerotherapy of large renal cysts via computed tomography (CT). Retrospective study reviewed 71 patients (61.0 ± 13.2years; M:F = 32:39) who underwent pretreatment CT and were treated with sclerotherapy of a large (> 5cm) renal cyst (mean volume: 279.8cc) using 99% ethanol from January 2010 to February 2019. Patients were followed up at least two times, short-term (defined as < 6months, median 2.1months) and long-term (defined as > 1year, median 15.5months), via ultrasound or CT. Suboptimal response was defined as the volume of residual cyst > 20mL in each follow-up. Predictive variables of radiologic findings and radiomics features were analyzed using logistic regression analysis. Suboptimal response rates were 33.8% and 18.3% at short-term and long-term follow-ups, respectively. In radiologic findings, patients with suboptimal response in the short-term follow-up showed a more frequent estimated cyst volume ≥ 270mL (OR 14.8, 95% CI 3.9-55.9, p < 0.001) and sinus protrusion (OR 7.0, 95% CI 1.7-28.5, p = 0.007). Cyst volume ≥ 270mL was also associated with suboptimal response in the long-term follow-up (OR 4.6, 95% CI 1.3-16.9, p = 0.021). When radiomics features were combined, the area under the curve increased from 0.83 to 0.86 and from 0.68 to 0.82 to predict suboptimal response in short-term and long-term follow-ups, respectively. Greater estimated volume, sinus protrusion, and radiomics features of the cysts in pretreatment CT can help predict suboptimal response of renal cyst after sclerotherapy.