Abstract
Objective To predict the secondary structure and B/T cell epitopes of Hev b 1 protein for latex by application of bioinformatics software.Methods The amino acid sequence of Hev b 1 was obtained from the Uniprot database.The secondary structure of Hev b 1 was predicted by the GOR 4 online server.DNAStar Protean was applied to predict the B cell epitopes by analyzing the hydrophilicity,surface probability,flexible regions and antigenic index of Hev b 1,and the T cell epitopes were predicted through the NetMHC Ⅱ 2.2 server.Results The dominant B cell epitopes of Hev b 1 were on the regions of 1-14 and 40-46 and the dominant T cell epitopes were on 56-64,76-84 and 97-116.Conclusions We obtain the dominant B/T cell epitopes of latex allergen Hev b 1 by bioinformatic analysis,which lays a solid foundation for designing antibodies and modifying allergenicity of Hev b 1. Key words: Latex allergen; Hev b 1; Epitopes; Secondary structure
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