Abstract

The paper is devoted to the application of machine learning methods to the prediction of the development of gestational diabetes mellitus in early pregnancy. Based on two publicly available databases, study assesses influence of such features as body mass index, thickness of triceps skin folds, ultrasound measurements of maternal visceral fat, first measured fasting glucose, and others a predictors of gestational diabetes mellitus. The supervised machine learning methods based on decision trees, support vector machines, logistic regression, k-nearest neighbors classifier, ensemble learning, Naive Bayes classifier, and neural networks were implemented to determine the best classification models for computerized gestational diabetes mellitus disease prediction. The accuracy of the different classifiers was determined and compared. Support vector machine classifier demonstrated the highest accuracy (83.0% of total correctly prognosed cases, 87.9% for healthy class, and 78.1% for gestational diabetes mellitus) in predicting the development of gestational diabetes based on features from Pima Indians Diabetes Database. Extreme gradient boosting classifier performed the best, comparing to other supervised machine learning methods, for Visceral Adipose Tissue Measurements during Pregnancy Database. It showed 87.9% of total correctly prognosed cases, 82.2% for healthy class, and 93.6% for gestational diabetes mellitus).

Highlights

  • Gestational diabetes mellitus (GDM) is a disease characterized by hyperglycemia, which was first detected during pregnancy

  • Attention should be paid to the impact of body mass index (BMI) and diabetes pedigree function, which provides diabetes mellitus history in relatives and distinguished patients genetically predisposed to the diabetes mellitus disease

  • Visceral adipose tissue thickness, thickness of triceps skin folds, diabetes pedigree function, and first-trimester fasting plasma glucose level are the parameters, which should definitely be taken into account in predicting of gestational diabetes mellitus and its adverse consequences

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Summary

Introduction

Gestational diabetes mellitus (GDM) is a disease characterized by hyperglycemia (increased blood glucose levels), which was first detected during pregnancy. To overcome the physiological insulin resistance and maintain normal pregnancy glucose levels in the blood, there is a compensatory increase in insulin secretion by the pancreas of the healthy pregnant women. In pregnant women with a hereditary predisposition to diabetes or obesity (body mass index greater than 30 kg/m2), the existing insulin secretion does not always overcome the physiological insulin resistance that develops in the second half of pregnancy. This leads to the increase in blood glucose levels and the development of gestational diabetes [1,2,3,4,5]. The mother's chronic hyperglycemia damages the development of the fetus

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