Abstract
The medicinal plant contains several active compounds that work synergistically and targets some proteins. In order to obtain an herbal formula that can target two or more proteins from a disease, it is necessary to analyze the effect of compound interactions contained in medicinal plants. In 2015, Li Y et al. introduced a Network Target-based Identification of Multicomponent Synergy (NIMS) method to calculate the synergistic effect between two compounds for rheumatic disease in Traditional Chinese Medicine. However, research on interactions between three or more compounds is also needed to create an effective formula that can work on multiple targets. In this study, we proposed a novel method called One-Against-One NIMS (OAO-NIMS) to predict the synergistic effect of three compounds. Our proposed method was applied to examine compound interactions related to diabetes mellitus disease, and the best combination of three compounds was obtained by Gliquidone, Glipizide, and Mitiglinide with synergy score of 0.425.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: IOP Conference Series: Earth and Environmental Science
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
