Prediction of sulfadiazine solubility in some cosolvent mixtures using non-ideal solution models

Abstract

The experimental data of sulfadiazine in (methanol + water), (ethanol + water) and (1-propanol + water) cosolvent mixtures at some temperatures were correlated using non-ideal solution models, namely, the modified Apelblat and Buchowski-Ksiazaczak equations and the van’t Hoff equation. The calculated results agreed well with the experimental data. According to the Buchowski equation, the solubility of sulfadiazine in the three co-solvent mixtures shows important deviations from ideality, which is consistent with the literature.