Abstract
The prediction of stability and pharmaceutical formulation of compounds of unknown structure are especially important in the antibiotic age. The kinetics of solution degradation of the antibiotic complex of the structurally unknown strepto-varicins are studied spectrophotometrically and equations obtained to characterize degradation as a function of pH. Bioassay has been correlated with spectra and conditions given for maximum stability of assay standards and preservation of yield. A mechanism is proposed that accounts for the available data and predicts the properties of degradation intermediates. The application of an analog computer to kinetic interpretation is given. Kinetic conditions for the differential assay of streptovaricin C were derived.
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