Abstract
BackgroundKnowing the submitochondria localization of a mitochondria protein is an important step to understand its function. We develop a method which is based on an extended version of pseudo-amino acid composition to predict the protein localization within mitochondria. This work goes one step further than predicting protein subcellular location. We also try to predict the membrane protein type for mitochondrial inner membrane proteins.ResultsBy using leave-one-out cross validation, the prediction accuracy is 85.5% for inner membrane, 94.5% for matrix and 51.2% for outer membrane. The overall prediction accuracy for submitochondria location prediction is 85.2%. For proteins predicted to localize at inner membrane, the accuracy is 94.6% for membrane protein type prediction.ConclusionOur method is an effective method for predicting protein submitochondria location. But even with our method or the methods at subcellular level, the prediction of protein submitochondria location is still a challenging problem. The online service SubMito is now available at:
Highlights
Knowing the submitochondria localization of a mitochondria protein is an important step to understand its function
Result Because there exists no other method for predicting protein submitochondria location, we are unable to provide a comparison with other methods
We develop a computational system for predicting protein submitochondria location only from its primary sequence
Summary
Knowing the submitochondria localization of a mitochondria protein is an important step to understand its function. We develop a method which is based on an extended version of pseudo-amino acid composition to predict the protein localization within mitochondria. Mitochondria are subcellular organelles that appear only in eukaryotic cells. They are surrounded by two layers of membrane, the inner membrane and the outer membrane. Proteins which are localized within mitochondria play important roles in energy metabolism process. Outer membrane and matrix contain proteins which contribute to different procedures in energy metabolism. It has been proved that mitochondria are involved in several complex biological processes, like programmed cell death[1] and ionic homeostasis[2]. There are over 100 kinds of complex diseases related with mitochondria
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