Prediction of Protein Subcellular Localization Based on Microscopic Images via Multi‐Task Multi‐Instance Learning

Abstract

Protein localization information is essential for understanding protein functions and their roles in various biological processes. The image-based prediction methods of protein subcellular localization have emerged in recent years because of the advantages of microscopic images in revealing spatial expression and distribution of proteins in cells. However, the image-based prediction is a very challenging task, due to the multi-instance nature of the task and low quality of images. In this paper, we propose a multi-task learning strategy and mask generation to enhance the prediction performance. Furthermore, we also investigate effective multi-instance learning schemes. We collect a large-scale dataset from the Human Protein Atlas database, and the experimental results show that the proposed multi-task multi-instance learning model outperforms both single-instance learning and common multi-instance learning methods by large margins.