Abstract
The aim of the research was to study the relationship between the level of vaspin and the thickness of the intima-media of the carotid artery (CIMT), parameters of carbohydrate and lipid metabolism, functional state of the pancreas, markers of inflammation, and to create a mathematical model for the progression of atherosclerosis in patients with type 2 diabetes mellitus (DM-2) and chronic pancreatitis (CP).
 Materials and methods: Serum vaspin level in 114 people with DM-2 or CP and a combination of these diseases were obtained. The parameters of lipid and carbohydrate metabolism, inflammation and functional status of pancreas were studied. CIMT was measured by means of B-mode ultrasonography. The obtained data were processed by the methods of non-parametric statistics to study the dependence of the parameters on the group, questions of the statistical significance of differences between two unrelated groups, the tightness of the relationship between the analyzed parameters.
 Results: A statistically significant (p<0.05) increase in serum vaspin levels in patients with DM-2 compared with other studied groups was obtained. A reliable correlation between vaspin, carbohydrate metabolism and CIMT was obtained, and it appeared to be dependent on the presence of comorbid pathology. The value of vaspin / tumor necrosis factor-α (TNF-α), starting from which CIMT increase is considered present, was calculated.
 Conclusions: Undertaken study confirmed the positive connection of vaspin with insulin resistance markers, but also demonstrated that serum vaspin levels is positively associated with CIMT. A mathematical model for predicting the progression of atherosclerosis in patients with the studied pathology was developed. It was demonstrated that the Vaspin/TNF-α ratio can be used as a marker of early atherosclerotic lesion of vascular wall, indicating the role of vaspin in atherogenesis
Highlights
Due to a modern approach to treatment of type 2 diabetes mellitus (DM-2), it is easier to achieve disease compensation nowadays
One of the reasons for occurrence of cardiovascular events (CVE) is the presence of comorbid diseases in DM-2 and a number of other factors, namely: impaired lipid metabolism, inflammatory process, irregular blood glucose level control, which leads to increased time of blood glucose level being beyond the target range
We have found no studies of connection between serum vaspin levels and atherosclerosis in patients with isolated DM-2 and DM-2 combined with Chro nic pancreatitis (CP)
Summary
Due to a modern approach to treatment of type 2 diabetes mellitus (DM-2), it is easier to achieve disease compensation nowadays. Even when blood glucose level is under control, risk of cardiovascular events (CVE) remains in individuals with DM. One of the reasons for occurrence of CVE is the presence of comorbid diseases in DM-2 and a number of other factors, namely: impaired lipid metabolism, inflammatory process, irregular blood glucose level control, which leads to increased time of blood glucose level being beyond the target range. Chro nic pancreatitis (CP) is one of the most common comorbid diseases in DM-2. The incidence of DM-2 in CP is 40–60 % depending on the grade of pancreatic injury [1]. In patients with DM-2, atherosclerotic changes develop faster, and earlier, while reducing their lifetime [2]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
