Prediction of presepsin concentrations through commensurate decline in kidney function in the elderly

Abstract

BackgroundPresepsin is a useful biomarker to diagnose sepsis. However, the correlation between plasma presepsin concentrations and kidney function in the elderly with chronic kidney disease (CKD) remains to be elucidated. We determined whether plasma presepsin concentrations were influenced by kidney function decline in the elderly. MethodsOne hundred seventy outpatients with CKD aged ≥65 y were enrolled. Plasma presepsin concentrations were measured using immunoassay analysis. The relationship between plasma presepsin concentration and kidney function was assessed. ResultsThe median age of patients of this cohort was 778 (72–85) y and the mean estimated glomerular filtration rate was 51.8 ± 28.1 ml/min/1.73 m2. Plasma presepsin concentrations in those with CKD G4-G5 (362 pg/ml [273–553]) were significantly higher than in those with CKD G1-G2 (111 pg/ml [91–113]) and CKD G3 (145 pg/ml [124–205]) (p < 0.001, p < 0.001, respectively). A high correlation between plasma presepsin concentrations and kidney function was observed (R2 = 0.733, p < 0.001). Even after adjusting for confounders, plasma presepsin concentrations were independently associated with kidney function. ConclusionsIncreases in plasma presepsin concentrations were exponentially correlated to kidney function decline in the elderly with CKD.