Prediction of plasma myeloperoxidase on cardiovascular event of patients with stable angina pectoris

Abstract

Objective To explore the independent prognostic value of plasma myeloperoxidase (MPO) in cardiovascular event of patient with stable angina pectoris.Methods Two hundred and forty-seven patients with stable angina pectoris (defined as 50％ stenosis in any coronary vessel) were selected as our subjects and they all were followed up for 2 years.Plasma MPO and hsCRP concentrations were measured.The major adverse cardiovascular events (MACEs),including death,myocardial infarction and stroke,occurred in patients were recorded.Results All patients were divided into high MPO group (84 cases and plasma MPO concentrations over 320 mg/L) and low MPO group (163 cases,plasma MPO concentrations less than 320 mg/L).Compared with patients in low MPO group,the risk of occurring MACEs in high MPO group was higher(HR =1.67,95％ CI =1.32-2.57,P ＜ 0.05).There was positive correlation between plasma MPO and hsCRP concentrations (r =0.132,P ＜ 0.05).Conclusion MPO level may serve as a better prediction index for adverse cardiovascular events of patients with Stable angina pectorisindependently.MPO has relationship with hsCRP concentrations. Key words: Stable angina pectoris; Plasma myeloperoxidase; High-sensitivity C-reactive protein; Adverse cardiovascular events