Abstract
Introduction. An important problem of modern obstetrics is the development and improvement of methods for predicting fetal growth retardation (FGR) and pregnancy outcomes in this pathology, since there are no proven effective treatments for FGR. Purpose of the study — to develop prediction criteria for newborn hypotrophy and cumulative adverse perinatal outcome in pregnant women with FGR. Objective. To identify key predictive factors for adverse perinatal outcomes in pregnancy complicated by FGR. Material and methods. A case-control, cohort-based study was conducted that included 155 pregnant women with FGR, who were divided into two groups after delivery: Group 1 included 90 patients with neonatal hypotrophy and Group 2 included 65 patients without neonatal hypotrophy. A comprehensive analysis of clinical and anamnestic, laboratory and instrumental data, peculiarities of the course of pregnancy and perinatal outcomes was performed. FGR was determined on the basis of ultrasound fetometry. Results. Factors associated with neonatal hypotrophy and unfavorable perinatal outcome were: impaired blood flow in the uterine arteries and/or umbilical artery, early preeclampsia and scarcity of water. Protective factors were antibacterial therapy for intrauterine infection, administration of low-molecular-weight heparin in the first trimester, and acetylsalicylic acid starting from the 12th to 16th weeks of gestation. Conclusion. The most promising measures in the prevention of FGR and adverse perinatal outcomes in this pathology may be timely prescription of antithrombotic correction and treatment of genital infections.
Highlights
To identify key predictive factors for adverse perinatal outcomes in pregnancy complicated by fetal growth retardation (FGR)
A case-control, cohort-based study was conducted that included 155 pregnant women with FGR, who were divided into two groups after delivery: Group 1 included 90 patients with neonatal hypotrophy and Group 2 included 65 patients without neonatal hypotrophy
FGR was determined on the basis of ultrasound fetometry
Summary
Purpose of the study — to develop prediction criteria for newborn hypotrophy and cumulative adverse perinatal outcome in pregnant women with FGR. To identify key predictive factors for adverse perinatal outcomes in pregnancy complicated by FGR. ВВЕДЕНИЕ Задержка роста плода (ЗРП) — актуальная проблема современного акушерства и перинатологии, занимающая одно из ведущих мест в структуре перинатальной заболеваемости и смертности. Одно из последствий патологии формирования фетоплацентарного комплекса, ЗРП, в настоящее время диагностируется только во второй половине беременности, когда уже нет возможности и времени для проведения профилактических мероприятий. Несмотря на совершенствование и повышение точности ультразвуковых методов диагностики ЗРП, создание различных нормограмм роста, существует проблема дифференциальной диагностики плодов с задержкой роста и конституционально маловесных, физиологически развивающихся. Цель исследования — разработка критериев прогноза гипотрофии новорожденного и совокупного неблагоприятного перинатального исхода (СНПИ) у беременных с ЗРП на основании комплексного изучения клинико-анамнестических, лабораторных и инструментальных данных
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