Prediction of peak oxygen uptake from ratings of perceived exertion during a sub-maximal cardiopulmonary exercise test in patients with chronic obstructive pulmonary disease.

Abstract

We assessed the validity of predicting peak oxygen uptake ([Formula: see text]O2 peak) from the relationship between oxygen uptake ([Formula: see text]O2) and overall ratings of perceived exertion (RPE) obtained during the initial stages of a cardiopulmonary exercise test (CPET). Fifteen healthy participants and 18 patients with chronic obstructive pulmonary disease (COPD) performed a maximal CPET, during which [Formula: see text]O2 and RPE were measured until RPE15. Individual regressions between [Formula: see text]O2 and RPE ≤ 15 were extrapolated to RPE19 to predict [Formula: see text]O2 peak. Mean actual and predicted [Formula: see text]O2 peak were not significantly different in healthy women (18.9 ± 4.1 vs. 20.4 ± 4.5 mL kg(-1) min(-1), respectively) and men (28.9 ± 7.8 vs. 29.7 ± 8.5 mL kg(-1) min(-1), respectively), or in women (15.2 ± 4.7 vs. 15.8 ± 5.0 mL kg(-1) min(-1), respectively) and men (16.2 ± 4.4 vs. 17.4 ± 5.4 mL kg(-1) min(-1), respectively) with COPD (P = 0.067). Moreover, actual and predicted [Formula: see text]O2 peak were highly correlated in healthy participants and COPD patients (r ≥ 0.89; P < 0.001). The bias and 95 % limits of agreement were -1.0 ± 4.0 and -1.0 ± 4.6 mL kg(-1) min(-1) for healthy and COPD participants, respectively. [Formula: see text]O2 peak can be predicted with acceptable accuracy in healthy participants and patients with COPD from the individual relationship between [Formula: see text]O2 and RPE ≤ 15.