Abstract
It has been reported that orally active cephalosporin antibiotics are absorbed from the small intestine via the oligopeptide transporter (PepTl). In the present study, methods have been established to predict oral absorption of cephalosporins using the in vitro data obtained with rat intestinal brush border membrane vesicles (BBMV) or Caco-2 cells. Uptake into BBMV or Caco-2 cells via PepTl was estimated by subtracting the uptake at 4°C from that at 25 or 37°C, which was well correlated with the extent of oral absorption (F) according to the intestinal absorption model reported by Amidon at al. The present method gave fairly good prediction of oral absorption of cephalosporins (Tablel, Figs. 1 and 2).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
