Prediction of Nodal Metastasis in Lung Cancer Using Deep Learning of Endobronchial Ultrasound Images.

Abstract

Simple SummaryEndobronchial ultrasound-guided transbronchial aspiration is a minimally invasive and highly accurate modality for the diagnosis of lymph node metastasis and is useful for pre-treatment biomarker test sampling in patients with lung cancer. Endobronchial ultrasound image analysis is useful for predicting nodal metastasis; however, it can only be used as a supplemental method to tissue sampling. In recent years, deep learning-based computer-aided diagnosis using artificial intelligence technology has been introduced in research and clinical medicine. This study investigated the feasibility of computer-aided diagnosis for the prediction of nodal metastasis in lung cancer using endobronchial ultrasound images. The outcome of this study may help improve diagnostic efficiency and reduce invasiveness of the procedure.Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a valid modality for nodal lung cancer staging. The sonographic features of EBUS helps determine suspicious lymph nodes (LNs). To facilitate this use of this method, machine-learning-based computer-aided diagnosis (CAD) of medical imaging has been introduced in clinical practice. This study investigated the feasibility of CAD for the prediction of nodal metastasis in lung cancer using endobronchial ultrasound images. Image data of patients who underwent EBUS-TBNA were collected from a video clip. Xception was used as a convolutional neural network to predict the nodal metastasis of lung cancer. The prediction accuracy of nodal metastasis through deep learning (DL) was evaluated using both the five-fold cross-validation and hold-out methods. Eighty percent of the collected images were used in five-fold cross-validation, and all the images were used for the hold-out method. Ninety-one patients (166 LNs) were enrolled in this study. A total of 5255 and 6444 extracted images from the video clip were analyzed using the five-fold cross-validation and hold-out methods, respectively. The prediction of LN metastasis by CAD using EBUS images showed high diagnostic accuracy with high specificity. CAD during EBUS-TBNA may help improve the diagnostic efficiency and reduce invasiveness of the procedure.