Prediction of No Tropic Properties of Novel Drug Modafiendz using in-Silico Method

Abstract

The development and approval of new drug is a tedious, expensive and highly time-consuming task. The demand of new drugs is increasing, and the development of natural drugs and traditional drugs are re-emerging as a new strategic task. The in-silico techniques have boosted the development of potential drug candidates. One important category of drugs is nootropes. It improves the cognitive function, memory, motivation and creativity in healthy individuals. The demand of the nootropic drugs has skyrocketed in past few decades. Modafiendz is a novel drug that is often used by the consumers as it is having similarity in structure and property with modafinil (Nootropic drug). But no major studies have been carried out on this molecule, so remains an investigatory molecule. There are several in-silico techniques that can be used to predict the likeness, metabolic activity and pharmacological property of a molecule. In the current study, realizing the importance of modafiendz, various properties of modafiendz have been predicted like metabolism site, ADME properties, metabolite prediction and DNA adduct formation tendencies.The properties of modafiendz were found to be similar to modafinil in various regards of drug likeability, bioavailability, blood brain permeability (BBB), GI absorption and site of metabolism (SOM). The study suggests modafiendz as a better nootropic drug candidate, when compared to modafinil.