Abstract
PurposeNear-infrared diffuse optical spectroscopy (DOS) has been recently used to predict neoadjuvant chemotherapy response (NAC). In the present study, we explore the change in blood-oxygen content using DOS to predict NAC response against breast cancer.Materials and methodsA total of 20 patients were enrolled and underwent DOS scan with blood-oxygen detection before each treatment cycle. The first DOS scan was performed before NAC treatment (pretreatment), and subsequent scans were performed after each NAC treatment circle. Changes in blood content and oxygen content by DOS were evaluated and compared with tumor size, and their changes were analyzed in response versus nonresponse group.ResultsThirteen patients were classified into response and seven patients into nonresponse group. The tumor blood content value (−1.06 ± 0.43) and oxygen content value (0.48 ± 0.17) of DOS at pretreatment was significantly different from presurgery in response group (P < 0.05), but not in nonresponse group. In response group, the percentage change in blood content (median 91.19%) was significantly larger than tumor size (median 48.89%) (P = 0.0035), while in oxygen content (median 47.11%) is not (P = 0.2815). Comparing each cycle, the percentage change in blood content could distinguish responder from non-responder as early as after the first treatment cycle (19.1 versus 6.6%, P = 0.0265). Blood content percentage sensitivity was 76.9% and specificity was 85.7% (AUC 0.912), while oxygen content percentage sensitivity was 76.9% and specificity was 71.4% (AUC 0.797).ConclusionBoth blood and oxygen content measured by DOS could be used to discriminate responder to the treatment versus non-responder. Among the two, percentage change of blood content was more precise and earlier than that of oxygen content to predicted breast tumor response. The percentage change in blood content could distinguish responder from non-responder after the first treatment cycle.
Highlights
Breast cancer is considered one of the major cause of cancer-related mortality in women worldwide
We explore the change in blood-oxygen content using diffuse optical spectroscopy (DOS) to predict neoadjuvant chemotherapy response (NAC) response against breast cancer
The first DOS scan was performed before NAC treatment, and subsequent scans were performed after each NAC treatment circle
Summary
Breast cancer is considered one of the major cause of cancer-related mortality in women worldwide. Five percent of newly diagnosed breast cancers is locally advanced breast cancer (LABC) [8]. Women with LABC commonly have poor outcomes and required neoadjuvant chemotherapy (NAC) before surgery. As one important therapy of multimodality LABC treatment, NAC can either decrease large tumor bulk before mastectomy or allow breast-conserving therapy. After NAC, those patients with pathologic response have better prognosis than those without a response [2, 5]. Predicting the tumor response to NAC is critical in the multimodality LABC treatment and chemotherapy regimens could be changed in advance in case of a predicted poor response
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