Abstract
Purpose of the study. Solving the problem of searching for prognostic factors of metastatic lesion of regional lymph nodes among the morphological and molecular characteristics of the primary breast tumor will bring modern oncology closer to finding the optimal model for individualizing diagnosis and treatment of breast cancer. Materials and methods. The statistical analysis of clinical data and morphological factors obtained in the oncology department of the breast pathology of the Voronezh regional clinical oncological dispensary during a comprehensive study involving 223 patients was carried out. Only the stages I T1N0M0 and IIa T2N0M0 were taken into account. Results and discussion. The study found that patients with a lack of metastases are characterized by a relatively smaller average tumor size (20.43 ± 9.28 mm) than in patients with metastases (27.43 ± 12.4 mm), with 25 % of them having Size ≤10 mm, 50 % – from 10 to 34 mm and 25 % – ≥ 34 mm. The difference in groups on the basis of “age” is absent. A statistical relationship (p < 0.05) between the biological tumor subtype and its histological diagnosis, between the biological tumor subtype and histological diagnosis and the absence / presence of metastases in the lymph nodes (p <0.0001) was established. Conclusions. Thus, it was established that the histological and morphological study of the primary tumor provides the necessary information not only to determine its sensitivity to different types of systemic treatment and the choice of therapeutic tactics, but also to solve the problem of predicting the metastatic lesion of regional lymph nodes in breast cancer patients.
Highlights
The statistical analysis of clinical data and morphological factors obtained in the oncology department of the breast pathology of the Voronezh regional clinical oncological dispensary during a comprehensive study involving 223 patients was carried out
The stages I T1N0M0 and IIa T2N0M0 were taken into account
The study found that patients with a lack of metastases are characterized by a relatively smaller average tumor size (20.43 ± 9.28 mm) than in patients with metastases (27.43 ± 12.4 mm), with 25 % of them having Size ≤10 mm, 50 % – from 10 to 34 mm and 25 % – ≥ 34 mm
Summary
«HER2-позитивный (не люминальный)»: HER2 сверхэкспрессирован или амплифицирован; ЭР и ПР отсутствуют “HER2-positive (non-luminal)”: HER-2 is overexpressed or amplified; ER and PR are absent. ЭР и ПP отсутствуют; опухоль HER2негативная Both ER and PR are absent; the tumor is HER2-negative. ER – estrogen receptors, PR – progesterone receptors, HER2 (HER2/neu) – epidermal growth factor receptor. 2 представлены клинико-морфологические данные 223 пациенток, разделенных на группы по признаку «отсутствие/наличие метастазов в лимфоузлы». 2, исходные данные содержат как количественные (возраст пациентки, размер опухоли), так и качественные характеристики (гистологический диагноз, биологический подтип, квадрант). Сначала обратимся к числовым характеристикам (размер опухоли и возраст) и проведем их статистический анализ, предварительно разделив на группы по признаку отсутствия/наличия метастаз в лимфоузлы Клинико-морфологические данные больных раком молочной железы с отсутствием /наличием (Met 0 / Met 1) метастазов, N = 223 Table 2.
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