Prediction of Insulin Resistance by Modified Triglyceride Glucose Indices in Youth.

Kyungchul Song,Hye Sun Lee,Goeun Park,Han Saem Choi,Ahreum Kwon,Jun Suk Oh,Youngha Choi,Hyun Wook Chae,Junghwan Suh,Ho-Seong Kim

doi:10.3390/life11040286

Abstract

The triglyceride glucose (TyG) index, derived from a combination of fasting glucose and triglycerides, has been suggested as a useful marker for insulin resistance (IR), in addition to modified TyG indices that combine obesity parameters. This study investigated the association and utility of TyG and modified TyG indices for IR prediction in youth. Based on the Korea National Health and Nutritional Examination Survey, the data of 3728 youth aged 10–19 years were analyzed. Odds ratios (ORs) and 95% confidence intervals (CIs) of tertiles 2 and 3 for each parameter were calculated and compared with tertile 1 as a reference. To compare the parameters for identifying IR, receiver operating characteristic curves were plotted and the area under the curve (AUC) was calculated. The ORs and 95% CIs for insulin resistance (IR) progressively increased across tertiles of each parameter. Overall, all modified TyG indices presented higher ORs and AUC than the TyG index. The TyG-body mass index standard deviation score showed the largest AUC for IR detection in all subjects. In conclusion, TyG and modified TyG indices could be used as valuable markers for the prediction of IR in youth. Moreover, modified TyG indices had better diagnostic accuracy than the TyG index.

Highlights

Insulin resistance (IR), characterized by an inadequate physiological response with insensitivity to insulin, is a major risk factor for metabolic syndrome and cardiovascular diseases (CVD) [1,2,3]
waist circumference (WC), waist-to-height ratio (WHtR), glucose level, and proportion of subjects with central obesity or insulin resistance (IR) were higher in males than in females, while overall lipid levels were higher in females than in males
The triglyceride glucose (TyG)-body mass index (BMI), TyG-WC, and TyG-WHtR indices were higher in males than in females, while the TyG

Summary

Introduction

Insulin resistance (IR), characterized by an inadequate physiological response with insensitivity to insulin, is a major risk factor for metabolic syndrome and cardiovascular diseases (CVD) [1,2,3]. A systematic review revealed that the prevalence of metabolic syndrome was high, at 3.3% in children and 29.2% in obese children [4]. A population-based study in Korea found that the prevalence of metabolic syndrome had increased from 4.0% in 1998 to 7.8% in 2007 [5]. Considering the increasing prevalence of metabolic syndrome in youth and association of metabolic syndrome with risk of type 2 diabetes and CVD, it is important to detect IR in children and adolescents [6]. Homeostasis model assessment of insulin resistance (HOMA-IR)

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