Abstract
This paper proposes a NPEL (Nine-Pipeline & Ensemble Learning) strategy based on machine Learning algorithm to predict protein-protein interaction hotspots by training amino acid composition, surface area, amino acid chains and other complex/interface-related structural information. We applied Random Forest, Linear Svm, KNN, Gaussian Naive Bayes, Multi-layer Perceptron Neural Network, Adaboost, XGBoost etc. nine machine learning algorithms combination into an independent pipeline to predict protein hot spots, and the final results are optimized through voting and stacking scheme. In the stacking result of XGBoost and Logistic Regression, the highest accuracy is 0.8462 and improve the indicators of the pipeline results greatly.
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