Abstract
BACKGROUND:Intestinal fatty acid binding proteins (I-FABPs) are mainly expressed in the intestinal villi, which are the initial site of destruction in viral gastroenteritis.AIM:This study was designed to assess serum I-FABPs as a predictor of gut wall integrity loss in viral gastroenteritis.PATIENTS AND METHODS:This case-control cross-sectional study was conducted on 93 cases of acute viral gastroenteritis. Twenty-eight healthy children matching in age were recruited as control group. Serum I-FABPs were measured using ELISA technique. Viral detection and typing were done by PCR for adenovirus, and by Reverse transcriptase PCR for rotavirus, astrovirus and norovirus.RESULTS:Serum I-FABPs level was significantly higher in the cases compared to the controls and was also higher in the 46 rotavirus gastroenteritis cases compared to other viral gastroenteritis cases. Serum I- FABPs level was significantly higher in severely dehydrated cases as compared to mildly dehydrated ones (P=0.037).CONCLUSION:Serum I-FABPs could be used as an early and sensitive predictor marker of gut wall integrity loss in children with viral gastroenteritis and its level can indicate case severity.
Highlights
Acute viral gastroenteritis (GE) is one of the commonest causes of morbidity and mortality in very young aged children [1,2,3]
Serum Intestinal fatty acid binding proteins (I-FABPs) level was significantly higher in the cases compared to the controls and was higher in the 46 rotavirus gastroenteritis cases compared to other viral gastroenteritis cases
Serum levels of I-FABP were higher in GE cases group compared to control group (1026.4 pg/ml vs 267.9 pg/ml, respectively)
Summary
Acute viral gastroenteritis (GE) is one of the commonest causes of morbidity and mortality in very young aged children [1,2,3]. This is definitely due to the dehydrating diarrhea and might be due to secondary blood stream infection [4]. Four major viral pathogens associated with AGE are three RNA viruses (rotavirus, norovirus, and astrovirus) and one DNA virus (enteric adenovirus) [4,5,6]. Rotavirus remains the most common cause of severe childhood diarrhea worldwide and of diarrheal mortality in developing countries [10]. Intestinal fatty acid binding proteins (I-FABPs) are mainly expressed in the intestinal villi, which are the initial site of destruction in viral gastroenteritis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Open access Macedonian journal of medical sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
