Abstract
Today, it is known that the levels of neurotrophic factors alter in neuropsychiatric disorders such as major depressive disorder (MDD), schizophrenia, Alzheimer’s disease or Parkinson’s disease. In recent years, some studies demonstrated that MDD may occur as a result of the changes in neuronal plasticity at structural and molecular levels.
Highlights
Today, it is known that the levels of neurotrophic factors alter in neuropsychiatric disorders such as major depressive disorder (MDD), schizophrenia, Alzheimer’s disease or Parkinson’s disease
Serum levels of Epidermal growth factor (EGF) did not differ in the MDD (p=1.00), SZ (p=1.00) or schizophrenia with depression (SZD) (p=0.218) groups compared to the healthy controls
The following are the major findings of the present study: i) the serum brain-derived neurotrophic factor (BDNF) levels are lower in all three patient groups than in the control group; ii) the serum levels of EGF were not different from the control group; iii) there were no significant differences between the patient groups in terms of the serum BDNF and EGF levels
Summary
It is known that the levels of neurotrophic factors alter in neuropsychiatric disorders such as major depressive disorder (MDD), schizophrenia, Alzheimer’s disease or Parkinson’s disease. Subjects Study population comprised of patients diagnosed with schizophrenia (SZ), major depressive disorder (MDD) and schizophrenia with depression (SZD) and a healthy control group between 18-65 years of age. Serum levels of EGF did not differ in the MDD (p=1.00), SZ (p=1.00) or SZD (p=0.218) groups compared to the healthy controls.
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