Prediction of co-metabolic degradation of bisphenol A and phenol by kinetic modeling

Abstract

In this work, a model was proposed to describe the ability of Ralstonia eutropha for co-metabolic transformation kinetic of bisphenol A (BPA) as a non-growth substrate in the absence or presence of phenol as a growth substrate. The effects of cell growth, loss of transformation activity, endogenous cell decay, self-inhibition of BPA, loss of transformation activity, and competitive inhibition between BPA and phenol were included in the proposed model. The model then was validated by comparing the predicated and the experimental data. To evaluate the model predictions under different combinations of phenol/BPA concentrations, the kinetic parameters were individually determined. Therefore, BPA transformation and phenol utilization were predicted successfully by the model for a defined range of concentrations of phenol (15–100 mg.l −1 ) and BPA (5–40 mg.l −1 ). • Co-metabolic transformation of BPA and phenol by Ralstonia eutropha was studied. • Kinetic model was successfully developed to predict co-metabolic degradation. • 44% of the initial BPA was mineralized to CO 2 . • Intermediate compounds were detected by LC-MS.