Prediction of anterior chamber volume after implantation of posterior chamber phakic intraocular lens.

Yuki Takagi,Kazuo Ichikawa,Tomoya Nishida,Tomoaki Nakamura,Takashi Kojima,Andrzej Grzybowski

doi:10.1371/journal.pone.0242434

Yuki Takagi, Kazuo Ichikawa + Show 4 more

Open Access

https://doi.org/10.1371/journal.pone.0242434

Copy DOI

Abstract

PurposeTo predict the anterior chamber volume (ACV) after implantable collamer lens (ICL) implantation based on ICL size and parameters of anterior segment optical coherence tomography (AS-OCT).DesignRetrospective study.MethodsThis study included 222 eyes of 222 patients who underwent ICL implantation at Nagoya Eye Clinic. The patients were divided into two groups: prediction group, for creating the prediction equation (148 eyes, mean age: 32.11 ± 8.04 years), and verification group, for verifying the equation (74 eyes, mean age: 33.03 ± 6.74 years). The angle opening distance (AOD), anterior chamber width (ACW), ACV, anterior chamber depth, lens vault, angle-to-angle distance, angle recess area, and trabecular iris space area were calculated using AS-OCT. A stepwise multiple regression analysis was performed. After the creation of the prediction equation, its accuracy was verified in the verification group.ResultsThe ACV, AOD750, ACW, and ICL size were selected as explanatory variables to predict postoperative ACV. Mean predicted (114.2 ± 21.83 mm3) and actual postoperative ACVs (116.1 ± 25.41 mm3) were not significantly different (P = 0.269); absolute error was 10.59 ± 9.13 mm3. In addition, there was high correlation between actual and predictive ACV (adjusted R2 = 0.6996, p < 0.0001). Bland-Altman plot revealed that there was no addition or proportional error between predicted and actual postoperative ACV.ConclusionPostoperative ACV was accurately predicted using AS-OCT parameters and ICL size. This prediction equation may be useful for making decisions regarding ICL size.

Highlights

Implantable collamer lens (ICL; STAAR Surgical, Nidau, Switzerland) was initially used for refractive correction in patients with high myopia
The anterior chamber volume (ACV), AOD750, anterior chamber width (ACW), and ICL size were selected as explanatory variables to predict postoperative ACV
Postoperative ACV was accurately predicted using anterior segment optical coherence tomography (AS-OCT) parameters and ICL size. This prediction equation may be useful for making decisions regarding ICL size

Summary

Introduction

Implantable collamer lens (ICL; STAAR Surgical, Nidau, Switzerland) was initially used for refractive correction in patients with high myopia. ICL implantation has more advantages than do laser kerato-refractive surgeries such as laser in situ keratomileusis (LASIK); the former is associated with no cornea-related complications, such as corneal ectasia and chronic dry eye disease [2]. The conventional ICL sizing method specified by the manufacturer used horizontal corneal diameter and anterior chamber depth, but the angle condition was not considered. Several studies have shown that the ICL size can be accurately determined to ensure the optimum height for the postoperative vault (distance between ICL and crystalline lens) [3,4,5]. We suggested that the ICL size should be determined so that both the vault and the angle condition are optimal

Methods

Results

Conclusion