Abstract
ABSTRACT Yield is one of the most important quality indexes for the crystal produced by high-pressure crystallization such as supercritical antisolvent (SAS) crystallization. In this study, a prediction model of yield of the SAS crystallization was proposed in the first place. Then, an experiment that prepares the citric acid particle crystallization was conducted through SAS batch device. With the help of a uniform design method, the maximum yield (0.86) was obtained under the combination of process parameters (the initial concentration of solution 0.35 g/mL, the operating temperature of 33°C, the operating pressure of 12.5 MPa, and the holding time of 3.5 h), the regression equation between yield of crystallization and four factors was obtained, and the effects of each factor on the yield are as follows: initial solution concentration > operating pressure > operating temperature > holding time. Finally, the prediction model was verified by an experiment, and the results show that the average relative error between the values calculated by prediction model and the experimental ones is 9.77%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
