Abstract
BackgroundThe risk of a subsequent stroke following a minor stroke is high. However, there are no effective rating scales to predict recurrent stroke following a minor one. Therefore, we assessed the risk factors associated with recurrent ischemic stroke or transient ischemic attack (TIA) within one year of minor stroke onset in order to identify possible risk factors.MethodsEight hundred and sixty-three non-cardioembolic ischemic stroke patients in the Chinese IntraCranial AtheroSclerosis Study that presented with minor stroke, defined as an admission National Institutes of Health stroke scale (NIHSS) score of ≤3, were consecutively enrolled in our study. Clinical information and imaging features upon admission, and any recurrent ischemic stroke or TIA within one year was recorded. Cox regression was used to identify risk factors associated with recurrent ischemic stroke or TIA within the year following stroke onset.ResultsA total of 50 patients (6.1%) experienced recurrent ischemic stroke or TIA within one year of minor stroke onset. Multivariate Cox regression model identified lower admission NIHSS score (HR, 1.75; 95% CI, 1.32 to 2.33; P<0.0001), history of coronary heart disease (HR, 2.62; 95% CI, 1.17 to 5.86; P = 0.02), severe stenosis or occlusion of large cerebral artery (HR, 4.68; 95% CI, 1.87 to 11.7; P = 0.001), and multiple acute cerebral infarcts (HR, 2.61; 95% CI, 1.01 to 6.80; P = 0.05) as independent risk factors for recurrent ischemic stroke or TIA within one year.ConclusionsSome minor stroke patients are at higher risk for recurrent ischemic stroke or TIA. Urgent and intensified therapy may be reasonable in these patients.
Highlights
The chance of a subsequent stroke following a minor stroke is high with a 90 day recurrence risk of 10% to 20% [1]
Multivariate Cox regression model identified lower admission National Institutes of Health stroke scale (NIHSS) score (HR, 1.75; 95% CI, 1.32 to 2.33; P
Some minor stroke patients are at higher risk for recurrent ischemic stroke or TIA
Summary
The chance of a subsequent stroke following a minor stroke is high with a 90 day recurrence risk of 10% to 20% [1]. Compared to TIA patients, minor stroke patients may have different risk factors associated with recurrent ischemic stroke or TIA. Our study only enrolls minor stroke patients and aims to elucidate the factors associated with recurrent ischemic stroke or TIA within one year of minor stroke onset. We assessed the risk factors associated with recurrent ischemic stroke or transient ischemic attack (TIA) within one year of minor stroke onset in order to identify possible risk factors
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