Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma

Weilong Zhang,Ping Yang,Ye Zhang,Weiyou Liu,Xiaoliang Yuan,Zuozhen Yang,Jing Wang,Xue He,Xiaoni Liu,Hongmei Jing,Yuansheng Lin,Kai Hu,Xiuru Zhang,Wei Fu

doi:10.1186/s12967-018-1728-8

Abstract

BackgroundMultiple myeloma (MM) is the plasma cell tumor, which is characterized by clonal proliferation of tumor cells, with high risk of progression to renal impairment, bone damage and amyloidosis. Although the survival rate of patients with MM has improved in the past decade, most people inevitably relapse. The treatment and prognosis of MM are still urgent problems. Breast Cancer Antiestrogen Resistance 3 (BCAR3) is a protein-coding gene that is associated with many tumors. However, there have been few studies on the relationship of BCAR3 and MM.MethodsWe analyzed 1878 MM patients (1930 samples) from 7 independent datasets. First, we compared the BCAR3 expression level of MM patients in different stages and MM patients with different amplification of 1q21. Second, we analyzed BCAR3 expression levels in MM patients with different molecular subtypes. Finally, we explored the event-free survival rate (EFS) and overall survival rate (OS) of MM patients with high or low BCAR3 expression, including patients before and after relapse, and their therapeutic responses to bortezomib and dexamethasone.ResultsThe expression of BCAR3 showed a decreasing trend in stages I, II and III (P = 0.00068). With the increase of 1q21 amplification level, the expression of BCAR3 decreased (P = 0.022). Patients with high BCAR3 expression had higher EFS and OS (EFS: P < 0.0001, OS: P < 0.0001). The expression of BCAR3 gene before relapse was higher than that after relapse (P = 0.0045). BCAR3 is an independent factor affecting prognosis (EFS: P = 5.17E−03; OS: P = 3.33E−04).ConclusionWe found that high expression level of BCAR3 predicted better prognosis of MM patients. Low expression of BCAR3 at diagnosis can predict early relapse. BCAR3 is an independent prognostic factor for MM. BCAR3 can be used as a potential biomarker.

Highlights

Multiple myeloma (MM) is the plasma cell tumor, which is characterized by clonal proliferation of tumor cells, with high risk of progression to renal impairment, bone damage and amyloidosis
In summary, our data show that high expression levels of Breast Cancer Antiestrogen Resistance 3 (BCAR3) predict a better prognosis for MM patients
B, The expression of BCAR3 in different ISS stages were compared under different serotype stratification (FLC: Serum free light chain, IgA: Serum immunoglobulin A, IgG: serum immunoglobulin G)

Summary

Introduction

Multiple myeloma (MM) is the plasma cell tumor, which is characterized by clonal proliferation of tumor cells, with high risk of progression to renal impairment, bone damage and amyloidosis. The treatment and prognosis of MM are still urgent problems. Breast Cancer Antiestrogen Resistance 3 (BCAR3) is a protein-coding gene that is associated with many tumors. MM is a B cell differentiated tumor characterized by clonal proliferation of tumor cells [1,2,3]. Zhang et al J Transl Med (2018) 16:363 dehydrogenase) to better assess patient prognosis [7]. Gene expression profiling (GEP) is important for revealing MM molecular heterogeneity of different patients. Recurrence is a major problem in most MM patients. Among all MM patients, early recurrence and poor prognosis are about 10% to 15% [10]

Methods

Discussion

Conclusion