Abstract
Nanoviridae is a family of single stranded DNA viruses which infect the plants through their phloem tissues. The few members of these viruses are now turning towards animals. It includes two genera, Nanovirus and Babuvirus. Nanovirus includes three species namely Faba beans necrotic yellows virus (FBNYV), Milk vetch dwarf virus (MVDV) and Subterranean clover stunt virus (SCSV) while Babuvirus have two species accounted yet, namely Abaca bunchy top virus (ABTV) and Banana bunchy top virus (BBTV). The viral coat proteins are likely to be responsible for many diseases in plants as well as animals. The intra-genomic changes or post translational modifications with in SCSV have decreased the length of the sequence, but increased the antigenic potential and numbers of antigenic binding regions on the surface of the protein. We have predicted the most probable responsible antigenic determinants and MHC binders within the viruses in Nanoviridae family. MHC molecules play a crucial role in host immune response. The nonamers of antigenic determinants in Nanoviridae family viral coat proteins are highly sensitive to H-2Kd and I-Ag7 molecules. The species within particular genera shows their common epitopes along with diverse colleague epitopes. These common antigenic peptides can be used as their identifi ers. These identifi ers along with their diverse colleagues could be most informative for antidotes production against themselves. Also, these are important for synthetic peptide vaccine production against the relevant viruses.
Highlights
Nanoviridae is a family of single stranded DNA viruses which infect the plants through their phloem tissues
The epitopes of Nanoviridae family have been predicted by comparative analysis of greatest hydrophilic regions
The nanoviruses attack plants mostly, the major histocompatibility complex (MHC) binding peptide and their increasing competence forecast be a sign of future host could be a man
Summary
Nanoviridae is a family of single stranded DNA viruses which infect the plants through their phloem tissues. They are characterized by non enveloped, spherical virions of 17-20 nm in diameter with icosahedral symmetry and are transmitted by aphids in a persistent but not in a propagative manner. These viruses retained when the vector moults, don’t multiply in a vector. In addition to genomic DNA, satellite-lake DNA are commonly found, usually encoding for Rep proteins. These satelliterep proteins are only able to initiate replication of their genomic
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