Abstract
Objective To predict and identify the frameshift sequences in the genome of Schistosoma japonicum.Methods Perl software was used to predict candidate sequences with pseudoknots of S.japonicum automatically.The stable sequences were searched based on the calculation of the minimum free energy and the FSfinder software was used to predict frameshift sites of the sequences,which were compared with proteome database by BLAST.Results From the 8 452 sequences in the S.japonicum database,26 candidate sequences containing both pseudoknot and corresponding frameshift site were selected and the protein Sjimportin bearing frameshift with the evidence in proteome database of S.japonicum was found.Conclusion Combining the RNA pseudoknots prediction software and frameshift prediction software,the database of S.japonicum frameshift has been built and the evidence of frameshift for Sjimportin has been got. Key words: Schistosoma japonicum; Frameshift; Pseudoknot; Bioinformatics
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