Abstract
Great progress achieved in treatment of multiple myeloma (MM) over the past decade changed overall perception of importance of minimal residual disease (MRD) assessment. Since new drugs induce deep responses, MRD must be evaluated using sensitive techniques, such as allele specific PCR (ASO-PCR), next-generation sequencing (NGS) or flow cytometry. MM is a genetically heterogeneous disease characterized by multiple focal lesions in the bone marrow (BM). BM samples are typically used for analysis, but currently an alternative approach called liquid biopsies, which utilize body fluids for analysis of various molecules and cells, is intensively studied.
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