Abstract
ABSTRACT The all experimental solubility data of sulphamethazine in {acetonitrile (1) + water (2)} binary solvent mixtures at temperature range from (278.15 to 323.15) K have been carefully reanalysed. Then, a minimum number of experimental solubility data has been chosen to predict the solubility data at all possible solvent compositions and temperatures using interpolation technique. The predicted data was compared with the experimental data employing the average absolute percentage deviation (AAPD) as an accuracy criterion. The preferential solvation analyses based on the inverse Kirkwood-Buff integrals and also apparent thermodynamic properties were conducted employing the simulated data and the obtained results were compared with those obtained employing all data points. Gibbs energy and preferential solvation follow similar trends but enthalpy and entropy of dissolution exhibit significant differences.
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