Predicting the Sensory Consequences of Self-Generated Actions: Pre-Supplementary Motor Area as Supra-Modal Hub in the Sense of Agency Experience.

Silvia Seghezzi,Laura Zapparoli

doi:10.3390/brainsci10110825

Abstract

Sense of agency refers to the feeling that one’s self-generated action caused an external environment event. In a previous study, we suggested that the supplementary motor area (SMA), in its anterior portion (pre-SMA), is a key structure for attributing the sense of agency for the visual consequences of self-generated movements. However, real-life actions can lead to outcomes in different sensory modalities, raising the question of whether SMA represents a supra-modal hub for the sense of agency. Here, we compared the agency experience for visual and auditory outcomes by taking advantage of the intentional binding effect (IB). We observed discrete time-windows for the agency manifestation across different sensory modalities: While there was an IB at 200 ms delay between the action and the visual outcome, a time compression was observed when the auditory outcome followed the action by 400 ms. The magnitude of the IB was mirrored by meaningful brain activity in the pre-SMA but only at the specific delay when a sizeable IB was seen. We conclude that attributing consequences of self-generated movements to one’s action is based on similar mechanisms across sensory modalities and that those mechanisms are related to the functioning of the motor system.

Highlights

According to theories on sensorimotor control [1,2,3], predicting actions’ sensory consequences is essential to accomplish the current motor programs and efficiently process the incoming sensory stimuli
We showed that the sense of agency is associated with a specific brain network, including the pre-supplementary motor area and dorsal parietal cortex, which activity was positively correlated with the degree of the
We looked for possible differences between the visual and auditory domains in the behavioral manifestation of the sense of agency experience, i.e., the intentional binding effect at different action-outcome delays

Summary

Introduction

According to theories on sensorimotor control [1,2,3], predicting actions’ sensory consequences is essential to accomplish the current motor programs and efficiently process the incoming sensory stimuli. It contributes to attributing the external effects of self-generated movements to oneself (“I did that”). This latter ability has been defined as “sense of agency, and it arises when predictions about the possible consequences of a voluntary action match the actual external outcome [4]. We explored the brain mechanisms underlying the sense of agency through an fMRI experiment based on visual stimuli [5]. We showed that the sense of agency is associated with a specific brain network, including the pre-supplementary motor area (pre-SMA) and dorsal parietal cortex, which activity was positively correlated with the degree of the

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