Predicting post-hepatectomy liver failure and postoperative complications after major hepatectomy

Abstract

Background: Post-hepatectomy liver failure (PHLF) is a well-known and serious complication following major hepatectomy with a mortality rate of up to 56%. However, PHLF in isolation does not comprehensively capture a patient's clinical course, as patients may have significant postoperative complications unrelated to liver function; adding the Comprehensive Complication Index (CCI) as an additional metric can address this issue. Our aim was to develop and validate prognostic models to predict clinically significant PHLF (ISGLS grades B and C) and CCI > 40 using both preoperative and intraoperative variables.