Abstract
The prognostic abilities of the MDRD and Cockcroft–Gault methods for estimating renal function were compared in a cohort study of 1287 patients with acute stroke admitted to a Scottish tertiary care teaching hospital. Using Cox regression analysis corrected for other prognostic variables, both the MDRD and Cockcroft–Gault equations predicted mortality independently of other prognostic factors. A 1 ml/min reduction in GFR as calculated by MDRD was associated with a 1.0% (95% CI: 0.3–1.6) increase in risk of death. A 1 ml/min reduction in creatinine clearance from the Cockcroft–Gault equation was associated with a 1.7% (95% CI: 0.9–2.6) increase in risk of death. The Cockcroft–Gault equation weakly predicted length of stay (r=0.066, p=0.02, Spearman's rank test). In conclusion, both methods independently predict early and late mortality in stroke patients, but the Cockcroft–Gault estimate has greater predictive power in this population.
Published Version
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