Predicting MicroRNA Mediated Gene Regulation between Human and Viruses.

Xin Shu,Xiaoshuang Liu,Jie Yang,Xinyuan Zang,Jin Wang

doi:10.3390/cells7080100

Abstract

MicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in mediating the interactions between humans and viruses. However, there is only limited information about Cross-Kingdom miRNA target sites from studies. To facilitate an extensive investigation on the interplay among the gene regulatory networks of humans and viruses, we designed a prediction pipeline, mirTarP, that is suitable for miRNA target screening on the genome scale. By applying mirTarP, we constructed the database mirTar, which is a comprehensive miRNA target repository of bidirectional interspecies regulation between viruses and humans. To provide convenient downloading for users from both the molecular biology field and medical field, mirTar classifies viruses according to “ICTV viral category” and the “medical microbiology classification” on the web page. The mirTar database and mirTarP tool are freely available online.

Highlights

MicroRNAs are a class of small (~24 nt), non-coding RNA molecules that play a critical role in fundamental cellular processes and many types of diseases
These findings indicate a common role of miRNAs in mediating the diversified interactions between humans and viruses
In we we provide a comprehensive miRNA miRNA

Summary

Introduction

MicroRNAs (miRNAs) are a class of small (~24 nt), non-coding RNA molecules that play a critical role in fundamental cellular processes and many types of diseases They negatively regulate gene expression by binding to the 30 -untranslated regions (30 UTR) of the target mRNAs in cells [1]. Pedersen et al [14] found that the overexpression of miR-196 and miR-448 significantly reduced the replication of HCV as they target the NS5A coding region and core of the HCV genome, respectively These findings indicate a common role of miRNAs in mediating the diversified interactions between humans and viruses. The new computational pipeline that was specially designed for human–virus interspecies miRNA target prediction was presented

Data Collection

The Prediction Tool

MirTar

Conclusions