Abstract
BackgroundAmniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal lung maturity. The purpose of this study was to validate a non-invasive fetal lung maturity test by counting lamellar bodies from a vaginal pool among women with preterm premature rupture of membranes.MethodsIn a prospective study, amniotic fluid specimens were collected from a vaginal pool from women after preterm premature rupture of membranes with gestational age between 27 and 36 completed weeks. Receiver operating characteristics curve was estimated to assess the threshold of lamellar bodies' count that may predict fetal lung maturity.ResultsSeventy-five specimens were collected of which 17 were between 32 to 34 weeks. A lamellar bodies' count of 28,000 or more predicted mature fetus 100% of the time (specificity) among all women and also among women between 32 to 34 weeks. The sensitivity was 72% among all and 92% when gestational age was between 32 to 34 weeks. A count of 8,000 or less, predicted respiratory distress syndrome with a sensitivity of 98% among the whole group.ConclusionCounting of lamellar bodies in amniotic fluid from a vaginal pool may be used to predict fetal lung maturity.
Highlights
Amniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal lung maturity
Respiratory distress syndrome (RDS) is the most common complication suffered by preterm neonates [1]
(page number not for citation purposes) http://www.rbej.com/content/7/1/112 samples, inadequate sample volume, cases where betamethasone was administered after the fluid analysis, delivery more than two days after fluid analysis, cases with maternal or fetal conditions that warranted expedite delivery, clinical amnionitis, inaccurate gestational age and cases in which women declined to participate were excluded
Summary
Amniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal lung maturity. The purpose of this study was to validate a non-invasive fetal lung maturity test by counting lamellar bodies from a vaginal pool among women with preterm premature rupture of membranes. P-PROM increases neonatal and maternal complications by increasing the risk of infection, cord accident and placental abruption [2]. Amniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal maturity. It is an invasive procedure with risks that include placental abruption, fetal maternal hemorrhage, infection and early onset of delivery [3]. The procedure is often technically (page number not for citation purposes)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
