Predicting insomnia severity using structure-function coupling in female chronic insomnia patients

Abstract

Functional connectivity between brain regions is constrained by the underlying structural pathways. However, how this structure-function coupling is disrupted in female patients with insomnia disorder is unclear. This study examines if the whole-brain pattern of structure-function coupling could be used to predict unseen female patients’ insomnia severity index. Resting-state functional MRI and diffusion-weighted imaging were performed in 82 female participants with chronic insomnia. Structure-function coupling was computed using the Spearman rank correlations between structural and functional connectivity profiles. Using relevance vector regression approach and 10-fold cross-validation, we predicted the individuals’ insomnia severity index using the pattern of whole-brain structure-function coupling. Finally, we extracted the contribution of each regional coupling to the prediction model. The pattern of structure-function coupling could be used to significantly predict unseen individuals’ insomnia severity index scores (r = 0.29, permutation P < 0.001; mean absolute error (MAE) = 4.59, permutation P < 0.001). Moreover, the brain regions with high functional hierarchy, including regions in the default mode network, mainly displayed negative contribution weights, while the regions with lower functional hierarchy, including occipital regions and the precentral gyrus, mainly displayed positive contribution weights. This is the first study to demonstrate an association between structure-function coupling and the insomnia severity index in females with insomnia disorder. Importantly, our data suggest that insomnia severity is associated with a reduction in structure-function coupling in higher-order brain regions and an increase in structure-function coupling in lower-order brain regions.