Abstract
(1) Background: This study investigates influential risk factors for predicting 30-day readmission to hospital for Campylobacter infections (CI). (2) Methods: We linked general practitioner and hospital admission records of 13,006 patients with CI in Wales (1990–2015). An approach called TF-zR (term frequency-zRelevance) technique was presented to evaluates how relevant a clinical term is to a patient in a cohort characterized by coded health records. The zR is a supervised term-weighting metric to assign weight to a term based on relative frequencies of the term across different classes. Cost-sensitive classifier with swarm optimization and weighted subset learning was integrated to identify influential clinical signals as predictors and optimal model for readmission prediction. (3) Results: From a pool of up to 17,506 variables, 33 most predictive factors were identified, including age, gender, Townsend deprivation quintiles, comorbidities, medications, and procedures. The predictive model predicted readmission with 73% sensitivity and 54% specificity. Variables associated with readmission included male gender, recurrent tonsillitis, non-healing open wounds, operation for in-gown toenails. Cystitis, paracetamol/codeine use, age (21–25), and heliclear triple pack use, were associated with a lower risk of readmission. (4) Conclusions: This study gives a profile of clustered variables that are predictive of readmission associated with campylobacteriosis.
Highlights
Campylobacteriosis is the most common form of culture-positive bacterial gastroenteritis worldwide, with the species C.jejuni and C.coli, inhabiting the intestinal tracts of both humans and animals, and accounting for up to 95% of human infections [1]
Andand clinical events recorded in primary care tocare predict the outcomes of campylobacteriosis teriosis patients admitted to hospital, classified as ‘readmission’
This study utilised 12,747,826 health records of 13,006 patients admitted to hospital with Campylobacter infections between 1990 and 2015, while there were 1062 readmissions
Summary
Campylobacteriosis is the most common form of culture-positive bacterial gastroenteritis worldwide, with the species C.jejuni and C.coli, inhabiting the intestinal tracts of both humans and animals, and accounting for up to 95% of human infections [1]. The disease burden has been estimated to be over 2.4 million people per annum in the USA [2,3]. In the UK, Campylobacter is thought to cause more than 280,000 cases of food poisoning annually, and be responsible for more than 100 deaths a year at an estimated cost of £900 million [4]. Campylobacter infections are typically attributed to the handling and consumption of chicken and, less frequently, with the consumption of unpasteurized milk, red meat, sausages, contaminated water, or transmission from household pets or farm animals. With relatively few identifiable outbreaks, so it is difficult to trace the sources and routes of transmission. Translation of exposure to infection remains poorly understood [2,5,6,7,8]
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