Predicting early anemia of premature infants with body weight less than 1500 g

Abstract

Early anemia of premature children is a characteristic disease of preterm infants, especially those with extremely low and very low body weight at birth. The study of new formation mechanisms will help to carry out preventive measures in a timely manner and prevent this pathology in the neonatal period.Objective. To study insulin-like growth factor-1 and protein-3, which binds insulin-like growth factor, to predict early anemia and its severe variant in premature infants.Characteristics of the children and research methods. The authors carried out the clinical and laboratory examination of 65 newborns of gestational age up to 32 weeks with a birth weight of less than 1500 g. The authors determined the content of insulin-like growth factor-1 and protein-3, which binds insulin-like growth factor in venous blood on the 3-5th day of life.Results. The authors revealed new predictors of early anemia of premature children: the content of protein-3, which binds insulin-like growth factor, on the 3-5th day of life of 0.766 μg/ml or less, and the content of insulin-like growth factor of 25.9 ng/ml or less predict the formation of early anemia in premature and very preterm patients. The authors established the predictors of the severe variant of early anemia of premature children, requiring blood transfusion, namely: the content of protein-3, which binds insulin-like growth factor, taking into account the anthropometric parameters of the child at birth. They developed and implemented the methods for predicting early anemia and its severe variant in premature patients.Conclusion. The results make it possible to timely carry out preventive measures in order to prevent the disease and improve the indicators of health and life quality in very premature patients.